unscienceunscience

Unscience comes from Middle English unscience ‘false knowledge or understanding’, from science ‘a science’, and ultimately from Latin sciō ‘to be able to’.

1. Latinc. 75 BCE–200 CEsciō¹‘to be able to’
2. Latin, derivedc. 75 BCE–200 CEsciēns²‘knowing, understanding’
3. Latin, derivedc. 75 BCE–200 CEscientia²
4. Middle Englishc. 1150–1500science³‘a science’
5. Middle English, derivedc. 1150–1500unscience⁴‘false knowledge or understanding’
6. Englishearliest quotation 1900unscience⁴

1. ¹ Wiktionary, Latin sciens
2. ² Wiktionary, Middle English science
3. ³ Wiktionary, Middle English unscience
4. ⁴ Wiktionary, English unscience
5. Earliest quotation in Wiktionary’s entry: 1900, John Vosburgh Stevens: “It has been used in medicine from time immemorial;…”.

Earlier history uncertain. See Wiktionary.